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A Human Model of Platelet-Leucocyte Adhesive Interactions During Controlled Ischaemia in Patients With Peripheral Vascular Disease.

 

AIMS: In humans, little is known about the effects of platelet-leucocyte interactions on blood viscosity and microvascular perfusion. This study testedthe hypotheses that (1) activation and interactions between platelets and leucocytes may have an impact on microvascular blood viscosity andperfusion in patients with stage II peripheral arterial occlusive disease, and (2) a powerful antiplatelet drug such as Clopidogrel might help to improvemicrovascular perfusion by reducing platelet-leucocyte activation and blood viscosity.

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