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OBJECTIVE: To review the benefits of statins in coronary artery disease management beyond their cholesterol-lowering effects.
DATA SOURCES: A MEDLINE search (1966-May 2000) was conducted using the following terms: lovastatin, pravastatin, simvastatin, atorvastatin, fluvastatin, cerivastatin, endothelium, plaque stabilization, antithrombotic effects.
STUDY SELECTION: English-language human studies and case reports.
AIM: To assess the lipid-modifying and pleiotropic effects of drugs of the statin group (simvastatin and pravastatin) and the fibrate group (gemfibrozil) in dyslipidemia patients.