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Metformin Improves Hemodynamic and Rheological Responses to L-Arginine in NIDDM Patients.


OBJECTIVE: The endothelium plays a pivotal role in the regulation of vascular tone by releasing nitric oxide (NO). Increased availability of L-arginine, the natural precursor of NO, induces vasodilatation and inhibits platelet activity. We studied the effect of metformin on hemodynamic and rheologicalresponses to L-arginine in patients with NIDDM.

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