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High-Dose Atorvastatin Treatment in Patients With Peripheral Arterial Disease: Effects on Platelet Aggregation, Blood Rheology and Plasma Homocysteine.

 

BACKGROUND: Statins are used for the treatment of hypercholesterolemia. Although they are well known to have pleiotropic effects, their dose-dependent influence on platelet aggregation, hemorheologic properties and the plasma levels of homocysteine in patients with peripheral arterial disease (PAD) has not been thoroughly investigated so far.

Trial of Atorvastatin in Rheumatoid Arthritis (TARA): Double-Blind, Randomised Placebo-Controlled Trial.

 

BACKGROUND: Rheumatoid arthritis is characterised by inflammatory synovitis, articular destruction, and accelerated atherogenesis. HMG-CoA (3-hydroxy-3-methylglutarylcoenzyme A) reductase inhibitors (statins) mediate clinically significant vascular risk reduction in patients withoutinflammatory disease and might have immunomodulatory function. We postulated that statins might reduce inflammatory factors in rheumatoid arthritis and modify surrogates for vascular risk.

Effect of Atorvastatin on Lipid Parameters, LDL Subtype Distribution, Hemorrheological Parameters and Adhesion Molecule Concentrations in Patients With Hypertriglyceridemia.

 

BACKGROUND AND AIM: Hypertriglyceridemia is a risk factor for atherosclerosis that is typically associated with high concentrations of adhesionmolecules, impaired hemorrheology and an unfavourable low-density lipoprotein (LDL) subtype distribution. We hypothesised that some of these riskmarkers might be beneficially influenced by lipid-lowering therapy with atorvastatin in hypertriglyceridemic patients.

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