Illuminating the Role of Blood Viscosity in Cardiovascular Diseases
Gregory Sloop, MD, retired pathologist and clinical research scientist, is editor of a new reference volume entitled Blood Viscosity: Its Role in Cardiovascular Pathophysiology and Hematology. Sloop served as Laboratory Medical Director and Chairman of Pathology at Benefis Hospitals, a large healthcare system in Great Falls, Montana serving over 230,000 people. Previously, Dr. Sloop was Associate Professor of Pathology with tenure at Louisiana State University School of Medicine in New Orleans.
Dr. Sloop is a pioneer in the field of clinical hemorheology. In 1996, he published the ground-breaking paper, A Unifying Theory of Atherogenesis, pinpointing blood viscosity as the root cause of atherosclerosis and describing how each of the conventional cardiovascular risk factors contributes to atherosclerosis by increasing blood viscosity.
Blood Viscosity: Its Role in Cardiovascular Pathophysiology and Hematology
Edited by Dr. Gregory D. Sloop
Book Description from the Publisher Nova Biomedical:
The impact of blood viscosity on health and disease has been neglected, even though viscosity is a fundamental property of any fluid. It is inversely proportional to flow, so increased blood viscosity predisposes to thrombosis. Blood viscosity is directly related to systemic vascular resistance, and so blood viscosity affects blood pressure. Blood viscosity is inversely proportional to perfusion, and increased viscosity adversely affects the performance of all organs. By viewing them through the perspective of viscosity, this book provides fresh insight into atherosclerotic cardiovascular disease, hypertension, metabolic syndrome, sepsis, hemolytic anemias, anemia of chronic disease, and aging.
Dr. Gregory Sloop along with other contributors have introduced a very valuable book centering on the importance of blood viscosity and the role that hemorheology plays in atherosclerosis. Specifically, chapters within the book provide insights into the pathophysiology and the role that blood viscosity interplays in this disease. With this added awareness, attention and knowledge of hemorheology, clinicians and other medical and scientific personnel, are provided a better understanding of the factors involved in this cardiovascular disease state. In addition this well written book provides a thought-provoking means to potentially develop novel therapeutic regimens for future treatments, as well as a current assessment of factors in a person’s life style, which can contribute to this disease.
- J.A. St. Cyr, MD, PhD, Retired, Cardiovascular Surgeon, Minneapolis, MN, USA
Gregory Sloop underlines in his brilliant and very original book the clinical importance of blood viscosity. By explaining the physical and hemodynamic role of hemorheology in the human organism he leads us to a new paradigm of how to interpret human physiology and pathology. This paradigm gives a far better explanation for the pathophysiology of atherothrombosis, the most common cause of death world-wide. It also gives new insight into the understanding and diagnosis of hypertension and how to discover new treatment options. Furthermore, according to this new paradigm, several forms of anemia should be understood as compensatory mechanisms and not necessarily considered as a failure of the organism, which should be simply corrected. The author combines in his book a genuine original insight in human physiology with a broad academic knowledge, which includes clinical praxis, pathology, basic cell theory, genetics as well as important principles of physics. Based on solid rational arguments and experimental evidence, his new paradigm even gives us a better understanding of how to link historical and cultural facts with the occurrence of epidemics such as atherosclerosis, hypertension, diabetes, etc. A paradigm shift will not be accepted easily within the world of scientists, but reading this book will certainly help to make such a transformation.
- Gheorghe Pop, MD, PhD, Clinical Cardiologist, Radboud Medical Center, Nijmegen, The Netherlands
Retired pathologist and erudite scholar, the editor of this book, Gregory Sloop, expands broadly upon his seminal paper “A Unifying Theory of Atherogenesis” which he published in the journal Medical Hypotheses in 1998. Back then, my research partner, cardiologist Kenneth Kensey, and I were developing similar theories, pointing to blood viscosity’s role in determining the work of the heart, vascular wall shear stress, and atherosclerosis. Dr. Sloop’s publication of his unifying theory hit us like a lightning bolt as it corroborated and in fact crystallized decades of our own work. Sloop has provided excellent historical perspectives on the role of blood viscosity in the development of atherosclerosis. He has given great insights on how abnormalities in blood viscosity create adverse hemodynamic conditions that lead to so called "vulnerable plaques." BLOOD VISCOSITY is a highly readable and unusual medical book. Part reference and part manifesto, BLOOD VISCOSITY is a well-researched and thoroughly cited scientific volume that is extraordinary insofar as it takes a stance, using historical perspectives, to advance a viewpoint on hemorheology, the physics of blood flow, and its role in cardiovascular diseases. Sloop and co-authors have provided a thought-provoking educational text that should be on the must-read list for the next generation of clinicians and medical scientists.
- Young I. Cho, PhD, Professor, Department of Mechanical Engineering & Mechanics, Drexel University, Philadelphia, Pennsylvania, USA