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Elevated plasma fibrinogen level is known to progress atherosclerosis and to be one of the risk factors for the occurrence of cardiovascular diseases. The objective of this study is to evaluate the changes in plasma fibrinogen level and blood rheology in patients with type II...
Type: Abstracts
Pravastatin has neuroprotective effects against aging but its role in brain injury remains unclear. This study evaluated the effects of pravastatin on theultrastructural changes and hemorheological parameters in rats after traumatic brain injury (TBI) of right parietal cortical contusion...
Type: Abstracts
BACKGROUND AND PURPOSE: Despite speculations, it is unknown whether statins affect wall shear stress (WSS). Therefore, the effect ofpravastatin on WSS was investigated. METHODS: In 355 elderly individuals participating in the PROSPER study (follow up after 3 years), the...
Type: Abstracts
Pravastatin sodium, a newly developed potent synthesis inhibitor of HMG-CoA (beta-hydroxy-beta-methylglutaryl-cocarboxylase-A) reductase(Sankyo Co., Ltd., Japan) was medicated, 10 approximately 15 mg/day (mean: 11.1 mg/day) for 10.2 weeks in mean, in 14 patients with...
Type: Abstracts
Blood viscosity (eta B) at shear rates 10 and 100s-1, plasma viscosity (eta P), hematocrit (Hct), and whole blood cholesterol (Chol) were measured in50 patients with a history of myocardial infarction or unstable angina pectoris. Erythrocyte morphology was also studied by scanning...
Type: Abstracts
Whole blood and plasma viscosity, red cell aggregability and deformability, and plasma fibrinogen have been compared between 20 patients withheterozygous familial hypercholesterolaemia (FH), without clinical arterial disease, and 20 age- and sex-matched controls. Plasma fibrinogen was...
Type: Abstracts
The role of hemostatic variables (which promote hemostatic plugs and thrombi) and rheological variables (which affect blood flow) in the pathogenesisof vascular diseases (ischemic heart disease, stroke, and peripheral arterial disease) is reviewed, with emphasis on epidemiological studies...
Type: Abstracts
OBJECTIVE: To review the benefits of statins in coronary artery disease management beyond their cholesterol-lowering effects. DATA SOURCES: A MEDLINE search (1966-May 2000) was conducted using the following terms: lovastatin, pravastatin, simvastatin, atorvastatin,...
Type: Abstracts

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