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Effects of Losartan on Insulin Sensitivity in Severe Hypertension: Connections Through Sympathetic Nervous System Activity?
Angiotensin II (Ang II) is one of the most potent vasoconstrictors, and the first specific and orally available Ang II-receptor antagonist, losartan (MK-954, DuP-753), has now come into clinical use. The primary site of insulin resistance, as measured by the glucose clamp technique, is skeletal...
Tags: Losartan, Whole blood viscosity (WBV), Hematocrit (Hct) (or packed cell volume PCV, erythrocyte volume fraction EVF), Fibrinogen, Blood glucose, Total cholesterol, Triglycerides
OBJECTIVE: The endothelium plays a pivotal role in the regulation of vascular tone by releasing nitric oxide (NO). Increased availability of L-arginine, the natural precursor of NO, induces vasodilatation and inhibits platelet activity. We studied the effect of metformin on hemodynamic and...
Effect of a High-Fructose Diet on Glucose Tolerance, Plasma Lipid and Hemorheological Parameters During Oral Contraceptive Administration in Female Rats.
Oral contraceptive (OC) use and increased fructose feeding have been associated with altered cardiometabolic effects. The effect of increased dietaryfructose during OC use on cardiometabolic parameters is unknown. We investigated the effects of a high-fructose diet on body weight gain, fasting...
Tags: Ethinyl Estradiol and Norgestrel, Whole blood viscosity (WBV), Plasma viscosity (PV), Hematocrit (Hct) (or packed cell volume PCV, erythrocyte volume fraction EVF), High-density lipoprotein cholesterol (HDL-C), Fibrinogen, Blood glucose, Triglycerides, Lipids
Effect of Treatment on Retinal Circulation, Platelet Aggregation and Blood Viscosity in Insulin-Dependent and Noninsulin-Dependent Diabetics.
In order to investigate the influence of diabetic treatment, especially insulin treatment on diabetic retinopathy, disc-to-macula circulation time, platelet aggregation and blood viscosity were observed before and after treatment for 5 years in 42 diabetics (17 insulin-dependent diabetics [IDD]...
Rheological studies were made on the blood of 12 diabetic patients after a period of poor diabetic control (HbA1 12.6 +/- 0.7% (mean +/- SD); mean home capillary blood glucose level 11.7 +/- 1.2 mmol/l), and after at least three months of improved control (HbA1 9.1 +/- 0.4%, p < 0.01; mean...
Tags: Insulin (Regular), Whole blood viscosity (WBV), Plasma viscosity (PV), Shear rate, Blood glucose, Fibrinogen
Decreased Red Blood Cell Aggregation Subsequent to Improved Glycaemic Control in Type 2 Diabetes Mellitus.
AIMS: Reports of rheological changes following intensification of metabolic control are limited and not concordant. The present study was designed to test the hypothesis that intensification of management of Type 2 diabetes (T2DM) with diet, exercise and insulin improves haemorheological...
Tags: Insulin (Regular), Erythrocyte aggregation (RBC aggregation), Plasma viscosity (PV), Whole blood viscosity (WBV), Blood glucose, Triglycerides, Total cholesterol