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  PURPOSE: Red blood cells (RBCs) express N-methyl D-aspartate (NMDA) receptors on their surface. We tested if NMDA receptor activation or inhibition had an influence on RBC deformability and aggregability. METHODS: Heparinized blood was drawn from healthy volunteers and centrifuged. RBCs were...
Type: Abstracts
  The haemorheological effects of felodipine extended release (ER), a new dihydropyridine calcium antagonist, were compared withhydrochlorothiazide (HCTZ) in 28 mild to moderate hypertensives (18 men and 10 women, aged 30-70 years) in a randomized, double-blind,crossover trial. Antihypertensive...
Type: Abstracts
  In spite of the recent flurry of interest in n-3 fatty acids, haemorheological effects have been somewhat neglected. When quantifying blood rheology bymeans of blood viscosity, plasma viscosity, haematocrit, red cell deformability and red cell aggregation measurements, it is observed that all...
Type: Abstracts
  In addition to their effects on blood pressure, antihypertensive agents may produce additional effects on blood rheology and arterial complianceabnormalities which may play a role in target-organ damage. However, these effects may depend only on the specific pharmacological properties of certain...
Type: Abstracts
  The effects of a beta-blocker, carvedilol, on peripheral hemodynamics and hemorheologic parameters were evaluated in 11 geriatric patients with essential hypertension [3 men and 8 women aged 62-79 years (mean, 68.6 years)]. Carvedilol was given orally after breakfast at a dose of 10 or 20 mg...
Type: Abstracts
  BACKGROUND: Statins are used for the treatment of hypercholesterolemia. Although they are well known to have pleiotropic effects, their dose-dependent influence on platelet aggregation, hemorheologic properties and the plasma levels of homocysteine in patients with peripheral arterial disease (...
Type: Abstracts
  Eight volunteers received lignocaine 75 mg i.m. Peak plasma lignocaine concentrations (mean 0.80 microgram ml-1; range 0.31-1.86 micrograms ml-1) were attained at 30 min. Haematocrit and red cell deformability remained unchanged. Lignocaine caused small but significant decreases in plasma...
Type: Abstracts
  This study was designed to examine changes of hemorheological parameters and red cell aggregation particularly in essential arterial hypertensionsubjects receiving antihypertensive diuretic therapy. Fifty six female subjects were enrolled in this study. Thirty seven subjects (group I) were...
Type: Abstracts
  To assess the effect of lovastatin on blood rheology, the hemorheological determinants fibrinogen, red cell aggregation, plasma viscosity, hematocrit and platelet aggregation (spontaneous and ADP-induced) were studied in 15 patients with type II hyperlipoproteinemia in the course of treatment...
Type: Abstracts
  OBJECTIVES: To evaluate the effects of transdermal hormone replacement therapy (HRT) on some biological cardiovascular risk factors, specificallythromboxane B2 level and plasma viscosity. Furthermore, we investigated Doppler flow modifications at the level of the uterine, internal carotid,...
Type: Abstracts

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