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  Eight volunteers received lignocaine 75 mg i.m. Peak plasma lignocaine concentrations (mean 0.80 microgram ml-1; range 0.31-1.86 micrograms ml-1) were attained at 30 min. Haematocrit and red cell deformability remained unchanged. Lignocaine caused small but significant decreases in plasma...
Type: Abstracts
  In addition to their effects on blood pressure, antihypertensive agents may produce additional effects on blood rheology and arterial complianceabnormalities which may play a role in target-organ damage. However, these effects may depend only on the specific pharmacological properties of certain...
Type: Abstracts
  In spite of the recent flurry of interest in n-3 fatty acids, haemorheological effects have been somewhat neglected. When quantifying blood rheology bymeans of blood viscosity, plasma viscosity, haematocrit, red cell deformability and red cell aggregation measurements, it is observed that all...
Type: Abstracts
  The haemorheological effects of felodipine extended release (ER), a new dihydropyridine calcium antagonist, were compared withhydrochlorothiazide (HCTZ) in 28 mild to moderate hypertensives (18 men and 10 women, aged 30-70 years) in a randomized, double-blind,crossover trial. Antihypertensive...
Type: Abstracts
  This study was designed to examine changes of hemorheological parameters and red cell aggregation particularly in essential arterial hypertensionsubjects receiving antihypertensive diuretic therapy. Fifty six female subjects were enrolled in this study. Thirty seven subjects (group I) were...
Type: Abstracts
  Peripheral artery disease is associated with altered blood rheologic properties, including increased viscosity and decreased red blood cell (RBC)deformability. Pentoxifylline and cilostazol are available therapies for intermittent claudication. Improvement of blood viscosity and erythrocyte...
Type: Abstracts
  Previous studies have explored the association between hemorheologic alterations and aspirin resistance, pointing out the possible interactionbetween hematologic components and platelet responsiveness to antiplatelet drugs. The aim of this study was to evaluate the association...
Type: Abstracts
  The present study in female rats determined the effects of experimental hyperthyroidsm on hemorheological parameters and fibrinogen concentration. To induce experimental hyperthyroidism L-thyroxine (0.4 mg/100 g fodder) was added to the fodder of the experimental group rats for 20 d....
Type: Abstracts
  Pravastatin has neuroprotective effects against aging but its role in brain injury remains unclear. This study evaluated the effects of pravastatin on theultrastructural changes and hemorheological parameters in rats after traumatic brain injury (TBI) of right parietal cortical contusion by a...
Type: Abstracts
  Eighteen patients with familial hypercholesterolemia treated with lovastatin (40 mg/day) for three months were studied to find out whether the drug induces modifications in the lipid composition of the erythrocyte membrane and whether these induce changes in the rheological behaviour of the red...
Type: Abstracts

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