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The Hemorheological Effects of Raloxifene in Postmenopausal Women With Osteoporosis. Results of a 3-Year Placebo-Controlled Clinical Trial.
Raloxifene, the prototype of the selective estrogen receptor modulators, has been associated with an increased risk of venous thromboembolism. As hemorheological factors may be involved in thrombus formation this placebo-controlled study investigated whether raloxifene was associated with changes...
Tags: Raloxifene, Whole blood viscosity (WBV), Plasma viscosity (PV), Hematocrit (Hct) (or packed cell volume PCV, erythrocyte volume fraction EVF), Fibrinogen
Abnormalities of Hemorheological, Endothelial, and Platelet Function in Patients With Chronic Heart Failure in Sinus Rhythm: Effects of Angiotensin-Converting Enzyme Inhibitor and Beta-Blocker Therapy.
BACKGROUND: To investigate the hypothesis that abnormalities of hemorheological (fibrinogen, plasma viscosity), endothelial (von Willebrand factor [vWF]), and platelet (soluble P-selectin) function would exist in patients with chronic heart failure (CHF) who are in sinus rhythm, we conducted a...
Relationship Between Plasma Essential Fatty Acids and Smoking, Serum Lipids, Blood Pressure and Haemostatic and Rheological Factors.
We aimed to determine whether levels of plasma fatty acids are correlated with other potential risk factors for cardiovascular disease, using a sampleof patients from a cross-sectional survey of the general population, in the City of Edinburgh. 306 men and women aged 55-74 years of whom half...
Tags: Omega-3-acid Ethyl Esters, Plasma viscosity (PV), Whole blood viscosity (WBV), Lipids, Triglycerides, Fibrinogen, High-density lipoprotein cholesterol (HDL-C)
Effects of Losartan on Insulin Sensitivity in Severe Hypertension: Connections Through Sympathetic Nervous System Activity?
Angiotensin II (Ang II) is one of the most potent vasoconstrictors, and the first specific and orally available Ang II-receptor antagonist, losartan (MK-954, DuP-753), has now come into clinical use. The primary site of insulin resistance, as measured by the glucose clamp technique, is skeletal...
Tags: Losartan, Whole blood viscosity (WBV), Hematocrit (Hct) (or packed cell volume PCV, erythrocyte volume fraction EVF), Fibrinogen, Blood glucose, Total cholesterol, Triglycerides
Whole blood and plasma viscosity, red cell aggregability and deformability, and plasma fibrinogen have been compared between 20 patients withheterozygous familial hypercholesterolaemia (FH), without clinical arterial disease, and 20 age- and sex-matched controls. Plasma fibrinogen was elevated in...
Tags: Plasma viscosity (PV), Whole blood viscosity (WBV), Fibrinogen, Erythrocyte aggregation (RBC aggregation), Erythrocyte deformability
Calcium Antagonists and Thiazide Diuretics Have Opposite Effects on Blood Rheology and Radial Artery Compliance in Arterial Hypertension: A Randomized Double-Blind Study.
In addition to their effects on blood pressure, antihypertensive agents may produce additional effects on blood rheology and arterial complianceabnormalities which may play a role in target-organ damage. However, these effects may depend only on the specific pharmacological properties of certain...
Tags: Hydrochlorothiazide, Whole blood viscosity (WBV), Plasma viscosity (PV), Fibrinogen, Hematocrit (Hct) (or packed cell volume PCV, erythrocyte volume fraction EVF), Erythrocyte aggregation (RBC aggregation), Erythrocyte deformability, Shear rate
Atorvastatin Improves Blood Rheology in Patients With Familial Hypercholesterolemia (FH) on Long-Term LDL Apheresis Treatment.
To determine the effect of atorvastatin on blood rheology in patients with familial hypercholesterolemia (FH) on regular LDL apheresis, weprospectively studied the rheological variables fibrinogen, plasma viscosity, red cell aggregation, whole blood viscosity, hematocrit and plateletaggregation...
Tags: Atorvastatin, Erythrocyte aggregation (RBC aggregation), Whole blood viscosity (WBV), Fibrinogen, Plasma viscosity (PV), Hematocrit (Hct) (or packed cell volume PCV, erythrocyte volume fraction EVF)
Effect of Testosterone Undecanoate on Hematological Profiles, Blood Lipid and Viscosity and Plasma Testosterone Level in Castrated Rabbits.
OBJECTIVE: The association between testosterone replacement therapy and cardiovascular risk remains controversial. Blood viscosity is a known individual risk factor for cardiovascular disease mortality. The objective of the present study was to investigate the effects of the long-acting...
Tags: Testosterone, Whole blood viscosity (WBV), Hematocrit (Hct) (or packed cell volume PCV, erythrocyte volume fraction EVF), Low-density lipoprotein cholesterol (LDL-C), High-density lipoprotein cholesterol (HDL-C), Shear rate, Triglycerides, Total cholesterol, Fibrinogen
Lipid-Modifying and Pleiotropic Effects of Gemfibrozil, Simvastatin and Pravastatin in Patients With Dyslipidemia.
AIM: To assess the lipid-modifying and pleiotropic effects of drugs of the statin group (simvastatin and pravastatin) and the fibrate group (gemfibrozil) in dyslipidemia patients. PATIENTS AND METHODS: Fifty eight patients with primary dysli pidemia were recruited for a 12-week treatment. Forty...
Tags: Gemfibrozil, Pravastatin, Simvastatin, Plasma viscosity (PV), Hematocrit (Hct) (or packed cell volume PCV, erythrocyte volume fraction EVF), Total cholesterol, Low-density lipoprotein cholesterol (LDL-C), Apolipoprotein A-I (apo A-I), Lipids, Antithrombin III, Triglycerides, High-density lipoprotein cholesterol (HDL-C), Apolipoprotein B (ApoB), Platelet aggregation, Platelet factor 4 (PF4), Platelets (or thrombocytes), α2-macroglobulins, Fibrinogen
Failure of Pentoxifylline or Cilostazol to Improve Blood and Plasma Viscosity, Fibrinogen, and Erythrocyte Deformability in Claudication.
Peripheral artery disease is associated with altered blood rheologic properties, including increased viscosity and decreased red blood cell (RBC)deformability. Pentoxifylline and cilostazol are available therapies for intermittent claudication. Improvement of blood viscosity and erythrocyte...
Tags: Cilostazol, Pentoxifylline, Whole blood viscosity (WBV), Lipids, Erythrocyte deformability, Fibrinogen, Erythrocyte sedimentation rate (ESR), Plasma viscosity (PV)