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Effects of Long-Acting Propranolol and Verapamil on Blood Pressure, Platelet Function, Metabolic and Rheological Properties in Hypertension.
The newly developed antihypertensive drugs, the long-acting beta-blocker propranolol and the sustained release calcium antagonist verapamil, arecompared in their antihypertensive, platelet function, rheological properties and metabolic effects. The trial was a double-blind, randomised, placebo-...
Tags: Verapamil, Propranolol, Plasma viscosity (PV), Whole blood viscosity (WBV), Fibrinogen, Erythrocyte deformability, Low-density lipoprotein cholesterol (LDL-C), High-density lipoprotein cholesterol (HDL-C), Platelets (or thrombocytes), Lipids, Platelet activation, Platelet aggregation
Effects of Omega-3 Polyunsaturated Fatty Acids on Plasma Indices of Thrombogenesis and Inflammation in Patients Post-Myocardial Infarction.
OBJECTIVE: To determine the effects of n-3 PUFAs supplementation on plasma indices of coagulation (fibrinogen), fibrin D-Dimer (an index ofthrombogenesis and fibrin turnover), endothelial damage/dysfunction (von Willebrand factor (vWf)), platelet activation (soluble P-selectin (sP-sel))...
Tags: Omega-3-acid Ethyl Esters, Total cholesterol, Low-density lipoprotein cholesterol (LDL-C), Triglycerides, P-selectin, Platelet activation, von Willebrand factor (vWF), Fibrinogen, Inflammation, Lipids, Plasma proteins
Elevated plasma viscosity is a predictor of atherosclerotic vascular disease and is a potential mechanism by which hypertriglyceridemia increasescardiovascular risk. Previous studies of plasma viscosity reduction in hypertriglyceridemic patients used medications that lowered both triglycerideand...
Effects of "Newer" and "Older" Antihypertensive Drugs on Hemorrheological, Platelet, and Endothelial Factors. A Substudy of The Anglo-Scandinavian Cardiac Outcomes Trial.
BACKGROUND: Different antihypertensive therapies may exert benefits via not only a reduction in blood pressure but also in improving the risk of thrombosis. METHODS: We tested the hypothesis that a more modern antihypertensive drug regimen (ie, amlodipine +/- perindopril) would have a more...
Tags: Amlodipine, Plasma viscosity (PV), Hematocrit (Hct) (or packed cell volume PCV, erythrocyte volume fraction EVF), White blood cells (WBC) (or leukocytes), von Willebrand factor (vWF), Fibrinogen, P-selectin
Effect of Medication With Pravastatin Sodium on Hemorheological Parameters in Patients With Hyperlipoproteinemia.
Pravastatin sodium, a newly developed potent synthesis inhibitor of HMG-CoA (beta-hydroxy-beta-methylglutaryl-cocarboxylase-A) reductase(Sankyo Co., Ltd., Japan) was medicated, 10 approximately 15 mg/day (mean: 11.1 mg/day) for 10.2 weeks in mean, in 14 patients with primaryhyperlipoproteinemia...
Tags: Pravastatin, Total cholesterol, High-density lipoprotein cholesterol (HDL-C), Whole blood viscosity (WBV), Fibrinogen, Adjusted whole blood viscosity (or hematocrit-corrected blood viscosity, normalized for Hct)
Altered Flow Properties of Blood and Increased Plasma Fibrinogen in Cyclosporin-Treated Renal Allograft Recipients.
BACKGROUND: Abnormalities in blood rheology may be factors contributing to cardiovascular complications and the progression of renal failure inkidney allograft recipients. The haemorheological variables haematocrit, fibrinogen, whole blood viscosity, plasma viscosity, erythrocyte...
Tags: Cyclosporine, Hematocrit (Hct) (or packed cell volume PCV, erythrocyte volume fraction EVF), Fibrinogen, Plasma viscosity (PV), Whole blood viscosity (WBV), Erythrocyte aggregation (RBC aggregation), Low-density lipoprotein cholesterol (LDL-C), High-density lipoprotein cholesterol (HDL-C), Total cholesterol, Triglycerides
Lovastatin Therapy in Hypercholesterolemia: Effect on Fibrinogen, Hemorrheologic Parameters, Platelet Activity, and Red Blood Cell Morphology.
The effect of lovastatin therapy on blood rheology was investigated in 26 hypercholesterolemic patients. Treatment with lovastatin was associated with a significant improvement in whole blood filtration time and a tendency toward normalization in red blood cell morphology. A significant increase...
Tags: Lovastatin, Fibrinogen, Platelet aggregation, Platelets (or thrombocytes), Whole blood viscosity (WBV), Plasma viscosity (PV)
Effects of Acute Insulin-Induced Hypoglycaemia on Haemostasis, Fibrinolysis and Haemorheology in Insulin-Dependent Diabetic Patients and Control Subjects.
1. The effects of acute hypoglycaemia on haemostasis, fibrinolysis, blood viscosity and erythrocyte aggregation were examined after acute insulin-induced hypoglycaemia in six normal male subjects and in six male patients with poorly controlled insulin-dependent diabetes. In the control...
Tags: Insulin (Regular), Whole blood viscosity (WBV), Fibrinogen, Plasminogen, von Willebrand factor (vWF), Erythrocyte aggregation (RBC aggregation)
Effects of Felodipine ER and Hydrochlorothiazide on Blood Rheology in Essential Hypertension--A Randomized, Double-Blind, Crossover Study.
The haemorheological effects of felodipine extended release (ER), a new dihydropyridine calcium antagonist, were compared withhydrochlorothiazide (HCTZ) in 28 mild to moderate hypertensives (18 men and 10 women, aged 30-70 years) in a randomized, double-blind,crossover trial. Antihypertensive...
Tags: Felodipine, Hydrochlorothiazide, Whole blood viscosity (WBV), Plasma viscosity (PV), Hematocrit (Hct) (or packed cell volume PCV, erythrocyte volume fraction EVF), Erythrocyte aggregation (RBC aggregation), Erythrocyte deformability, Fibrinogen
Primary Chylomicronemia in Patients With Severe Familial Hypertriglyceridemia Responds to Long-Term Treatment With (n-3) Fatty Acids.
Because it disturbs microcirculation, chylomicronemia can cause severe clinical complications such as acute pancreatitis. Dietary measures are very important in the prevention and treatment of this condition. Dietary supplementation with (n-3) fatty acids has been shown to be of benefit in short-...
Tags: Omega-3-acid Ethyl Esters, Triglycerides, Plasma viscosity (PV), Chylomicrons, Apolipoprotein B (ApoB), Lipids, Fibrinogen