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Effects of Felodipine ER and Hydrochlorothiazide on Blood Rheology in Essential Hypertension--A Randomized, Double-Blind, Crossover Study.
The haemorheological effects of felodipine extended release (ER), a new dihydropyridine calcium antagonist, were compared withhydrochlorothiazide (HCTZ) in 28 mild to moderate hypertensives (18 men and 10 women, aged 30-70 years) in a randomized, double-blind,crossover trial. Antihypertensive...
Tags: Felodipine, Hydrochlorothiazide, Whole blood viscosity (WBV), Plasma viscosity (PV), Hematocrit (Hct) (or packed cell volume PCV, erythrocyte volume fraction EVF), Erythrocyte aggregation (RBC aggregation), Erythrocyte deformability, Fibrinogen
Primary Chylomicronemia in Patients With Severe Familial Hypertriglyceridemia Responds to Long-Term Treatment With (n-3) Fatty Acids.
Because it disturbs microcirculation, chylomicronemia can cause severe clinical complications such as acute pancreatitis. Dietary measures are very important in the prevention and treatment of this condition. Dietary supplementation with (n-3) fatty acids has been shown to be of benefit in short-...
Tags: Omega-3-acid Ethyl Esters, Triglycerides, Plasma viscosity (PV), Chylomicrons, Apolipoprotein B (ApoB), Lipids, Fibrinogen
Haemorheological and Endothelial-Dependent Alterations in Heart Failure After ACE Inhibitor, Calcium Antagonist and Beta Blocker.
The aim of our study was to evaluate endothelium-dependent dilatation induced by an ACE-inhibitor, calcium antagonist and beta blocker in patientssuffering from heart failure (NYHA class II and III). We studied 34 patients (19M, 15F, mean age 76.96+/-8.82) in pharmacological wash-out for at least...
Tags: Ramipril, Carvedilol, Amlodipine, Whole blood viscosity (WBV), Fibrinogen, Plasminogen activator inhibitor-1 (PAI-1), Platelet aggregation
A Randomized Comparison of the Effects of Aspirin and Clopidogrel on Thrombotic Risk Factors and C-Reactive Protein Following Myocardial Infarction: the CADET Trial.
A randomized, double-blind multicenter trial-the Clopidogrel and Aspirin: Determination of the Effects on Thrombogenicity (CADET) trial-was carriedout to compare the effects of clopidogrel vs. aspirin on thrombotic variables and C-reactive protein (CRP), over a 6-month period of treatment, in...
Tags: Clopidogrel, C-reactive protein (CRP), Fibrinogen, von Willebrand factor (vWF), Plasma viscosity (PV)
Effects of N-3 Fatty Acids and Fenofibrate on Lipid and Hemorrheological Parameters in Familial Dysbetalipoproteinemia and Familial Hypertriglyceridemia.
There is increasing evidence that hemorrheological abnormalities are associated with an enhanced risk of atherosclerosis. The n-3 fatty acids (n-3-FA) have been shown to have beneficial effects on atherosclerosis in patients with dyslipoproteinemias. We studied 23 patients with elevated plasma...
Tags: Fenofibrate, Omega-3-acid Ethyl Esters, Lipids, Whole blood viscosity (WBV), Shear rate, Plasma viscosity (PV), Fibrinogen, Erythrocyte aggregation (RBC aggregation), Very low-density lipoprotein cholesterol (VLDL-C)
Influence of Atorvastatin Versus Simvastatin on Fibrinogen and Other Hemorheological Parameters in Patients With Severe Hypercholesterolemia Treated With Regular Low-Density Lipoprotein Immunoadsorption Apheresis.
Low-density lipoprotein (LDL) apheresis is a treatment option in patients with coronary artery disease and elevated LDL cholesterol concentrations ifmaximal drug therapy fails to achieve adequate LDL cholesterol reduction. This therapy is more effective when combined with strong lipid-lowering...
Tags: Atorvastatin, High-density lipoprotein cholesterol (HDL-C), Low-density lipoprotein cholesterol (LDL-C), Plasma viscosity (PV), Whole blood viscosity (WBV), Red cell filterability, Fibrinogen, Erythrocyte aggregation (RBC aggregation)
Lovastatin Therapy in Heterozygous Familial Hypercholesterolaemic Patients: Effect on Blood Rheology and Fibrinogen Levels.
Thirteen heterozygous familial hypercholesterolaemic patients were treated with lovastatin for 1 year, and were investigated for the effect on lipid profile, blood rheology and fibrinogen levels. A significant dose-dependent reduction in serum levels of total and LDL-cholesterol, Apo B and the...
Tags: Lovastatin, High-density lipoprotein cholesterol (HDL-C), Low-density lipoprotein cholesterol (LDL-C), Apolipoprotein B (ApoB), Lipids, Total cholesterol, Fibrinogen, Red cell filterability
Rheological studies were made on the blood of 12 diabetic patients after a period of poor diabetic control (HbA1 12.6 +/- 0.7% (mean +/- SD); mean home capillary blood glucose level 11.7 +/- 1.2 mmol/l), and after at least three months of improved control (HbA1 9.1 +/- 0.4%, p < 0.01; mean...
Tags: Insulin (Regular), Whole blood viscosity (WBV), Plasma viscosity (PV), Shear rate, Blood glucose, Fibrinogen
Effects of Atorvastatin Versus Fenofibrate on Lipoprotein Profiles, Low-Density Lipoprotein Subfraction Distribution, and Hemorheologic Parameters in Type 2 Diabetes Mellitus With Mixed Hyperlipoproteinemia.
Diabetic dyslipoproteinemia characterized by hypertriglyceridemia, low high-density lipoprotein (HDL) cholesterol, and often elevated low-density lipoprotein (LDL) cholesterol with predominance of small, dense LDL is a strong risk factor for atherosclerosis. It is unclear whether fibrate or...
Tags: Fenofibrate, Atorvastatin, Lipids, Fibrinogen, Plasma viscosity (PV), Erythrocyte aggregation (RBC aggregation), Triglycerides, High-density lipoprotein cholesterol (HDL-C), Low-density lipoprotein cholesterol (LDL-C)
Effect of Supplementation With Dietary Seal Oil on Selected Cardiovascular Risk Factors and Hemostatic Variables in Healthy Male Subjects.
The average daily consumption of seal oil by the Inuit people is approximately 8-9 g, yet there is very little information on the effect of seal oil consumption on cardiovascular disease risk factors. In this study, 19 healthy, normocholesterolemic subjects consumed 20 g of encapsulated seal oil...