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The effect of dietary fish oil (Omega-3 fatty acids--eicosapentenoic acid [EPA] and docosahexaenoic acid [DHA] on several mechanisms involved in immune, inflammatory and atherosclerotic vascular disease was determined in 12 subjects with systemic lupus erythematosus (SLE) and nephritis. These out...
Tags: Omega-3-acid Ethyl Esters, Whole blood viscosity (WBV), Inflammation, Very low-density lipoprotein cholesterol (VLDL-C), Triglycerides, High-density lipoprotein cholesterol (HDL-C), Erythrocyte deformability, Platelet aggregation
Ileum-Targeted Steroid Therapy in Rheumatoid Arthritis: Double-Blind, Placebo-Controlled Trial of Controlled-Release Budesonide.
In order to determine whether budesonide, which is believed to exert most of its anti-inflammatory effects in the intestinal tract, has a beneficial effecton disease activity in rheumatoid arthritis (RA), we treated 26 patients with active RA in double-blind fashion with either controlled ileal-...
Tags: Budesonide, Inflammation, Hemoglobin (Hgb), Erythrocyte sedimentation rate (ESR), Plasma viscosity (PV), C-reactive protein (CRP)
Improved Insulin Sensitivity by the Angiotensin II-Receptor Blocker Losartan is Not Explained by Adipokines, Inflammatory Markers, or Whole Blood Viscosity.
We have previously found improved insulin sensitivity after antihypertensive treatment with an angiotensin II-receptor blocker as compared with acalcium channel blocker in hypertensives. In this study, we compare the effect of these 2 principal different vasodilating agents on levels of...
Tags: Losartan, Amlodipine, Whole blood viscosity (WBV), Plasminogen activator inhibitor-1 (PAI-1), Tumor necrosis factor alpha (TNFα), Inflammation, C-reactive protein (CRP)
Adenosine Transport, Erythrocyte Deformability and Microvascular Dysfunction: an Unrecognized Potential Role for Dipyridamole Therapy.
Reperfusion injury and no-reflow phenomenon are known entities that contribute to persistent impairment in myocardial perfusion and regional myocardial dysfunction following restoration of epicardial coronary blood flow after a myocardial infarction. Following prolonged ischemia, oxidative stress...
Tags: Dipyridamole, Inflammation, Whole blood viscosity (WBV), Platelet aggregation, Erythrocyte deformability
The Atherosclerotic Risk Profile is Affected Differently by Fish Flesh With a Similar EPA and DHA Content but Different N-6/N-3 Ratio.
The aim of this study was to evaluate the effect of consuming gilthead sea bream fillets, with different n-6/ n-3 ratios, on atherosclerotic biomarkers.Twenty healthy subjects were included in a randomised single-blinded cross-over trial. Participants were randomized into 2 groups, both of which...
Tags: Omega-3-acid Ethyl Esters, Whole blood viscosity (WBV), Total cholesterol, Low-density lipoprotein cholesterol (LDL-C), Triglycerides, Inflammation, Red cell filterability, Lipids
Effects of Omega-3 Polyunsaturated Fatty Acids on Plasma Indices of Thrombogenesis and Inflammation in Patients Post-Myocardial Infarction.
OBJECTIVE: To determine the effects of n-3 PUFAs supplementation on plasma indices of coagulation (fibrinogen), fibrin D-Dimer (an index ofthrombogenesis and fibrin turnover), endothelial damage/dysfunction (von Willebrand factor (vWf)), platelet activation (soluble P-selectin (sP-sel))...
Tags: Omega-3-acid Ethyl Esters, Total cholesterol, Low-density lipoprotein cholesterol (LDL-C), Triglycerides, P-selectin, Platelet activation, von Willebrand factor (vWF), Fibrinogen, Inflammation, Lipids, Plasma proteins
Effect of Supplementation With Dietary Seal Oil on Selected Cardiovascular Risk Factors and Hemostatic Variables in Healthy Male Subjects.
The average daily consumption of seal oil by the Inuit people is approximately 8-9 g, yet there is very little information on the effect of seal oil consumption on cardiovascular disease risk factors. In this study, 19 healthy, normocholesterolemic subjects consumed 20 g of encapsulated seal oil...