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Transdermal Hormone Replacement Therapy and Doppler Findings in Normal and Overweight Postmenopausal Patients.
The aim of this study was to evaluate the effects of transdermal hormone replacement therapy on some biological cardiovascular risk factors,specifically the thromboxane B2 levels, plasma viscosity and the lipid profile. Furthermore, we investigated the Doppler flow modifications at the level of...
Does Additional Treatment With Fish Oil Mitigate the Side Effects of Recombinant Human Erythropoietin in Dialysis Patients?
Since fish oil has been reported to reduce platelet aggregability, to reduce blood viscosity by increasing red blood cell deformability and to lower blood pressure, we studied the effect of dietary supplementation with fish oil on the occurrence of adverse effects in patients receiving...
Tags: Omega-3-acid Ethyl Esters, Whole blood viscosity (WBV), Erythrocyte deformability, Platelet aggregation, Lipids
Effects of dietary supplementation with highly purified EPA (1.8-2.7 g/day) for 16 weeks on platelet and red blood cell function and serum lipidsconcentration were investigated in patients with various thrombotic diseases. Decreases in platelet aggregation, thromboxane formation in platelets,...
In order to investigate the effect of fenofibrate on microcirculation, 16 patients (5 female, 11 male, age 58 +/- 8 years) were studied with the aid ofnailfold capillaroscopy before and after treatment with 200 mg fenofibrate per day over six weeks. Fenofibrate resulted in a significant decrease...
Tags: Fenofibrate, Lipids, Fibrinogen, Total cholesterol, Low-density lipoprotein cholesterol (LDL-C), Apolipoprotein A-I (apo A-I), Apolipoprotein B (ApoB), Very low-density lipoprotein cholesterol (VLDL-C)
Lipid-Modifying and Pleiotropic Effects of Gemfibrozil, Simvastatin and Pravastatin in Patients With Dyslipidemia.
AIM: To assess the lipid-modifying and pleiotropic effects of drugs of the statin group (simvastatin and pravastatin) and the fibrate group (gemfibrozil) in dyslipidemia patients. PATIENTS AND METHODS: Fifty eight patients with primary dysli pidemia were recruited for a 12-week treatment. Forty...
Tags: Gemfibrozil, Pravastatin, Simvastatin, Plasma viscosity (PV), Hematocrit (Hct) (or packed cell volume PCV, erythrocyte volume fraction EVF), Total cholesterol, Low-density lipoprotein cholesterol (LDL-C), Apolipoprotein A-I (apo A-I), Lipids, Antithrombin III, Triglycerides, High-density lipoprotein cholesterol (HDL-C), Apolipoprotein B (ApoB), Platelet aggregation, Platelet factor 4 (PF4), Platelets (or thrombocytes), α2-macroglobulins, Fibrinogen
Effect of Supplementation With Dietary Seal Oil on Selected Cardiovascular Risk Factors and Hemostatic Variables in Healthy Male Subjects.
The average daily consumption of seal oil by the Inuit people is approximately 8-9 g, yet there is very little information on the effect of seal oil consumption on cardiovascular disease risk factors. In this study, 19 healthy, normocholesterolemic subjects consumed 20 g of encapsulated seal oil...
The possible antiatherogenic action of eicosapentaenoic acid (EPA) was pharmacologically investigated using purified and ethylesterified fish oilcontaining 75% EPA (EPA-E) in multiple oral doses in rats and rabbits. EPA-E showed dose-dependent prevention of thrombus formation in a vascular shunt...
Effect of HMG-CoA Reductase Inhibitors on Red Blood Cell Membrane Lipids and Haemorheological Parameters, in Patients Affected by Familial Hypercholesterolemia.
Eighteen patients with familial hypercholesterolemia treated with lovastatin (40 mg/day) for three months were studied to find out whether the drug induces modifications in the lipid composition of the erythrocyte membrane and whether these induce changes in the rheological behaviour of the red...
Tags: Lovastatin, Whole blood filterability (WBF), Lipids, Erythrocyte aggregation (RBC aggregation), Erythrocyte deformability
Effects of Long-Acting Propranolol and Verapamil on Blood Pressure, Platelet Function, Metabolic and Rheological Properties in Hypertension.
The newly developed antihypertensive drugs, the long-acting beta-blocker propranolol and the sustained release calcium antagonist verapamil, arecompared in their antihypertensive, platelet function, rheological properties and metabolic effects. The trial was a double-blind, randomised, placebo-...
Tags: Verapamil, Propranolol, Plasma viscosity (PV), Whole blood viscosity (WBV), Fibrinogen, Erythrocyte deformability, Low-density lipoprotein cholesterol (LDL-C), High-density lipoprotein cholesterol (HDL-C), Platelets (or thrombocytes), Lipids, Platelet activation, Platelet aggregation
Administration of Dietary Fish Oil Capsules in Healthy Middle-Aged Japanese Men With a High Level of Fish Consumption.
The nutritional effects of fish oil, which is rich in the n-3 polyunsaturated fatty acids, have been reported. In this randomized, placebo-controlled,double-blind, crossover study, we evaluated the effects of dietary fish oil capsules on the hematological parameters of healthy middle-aged...
Tags: Omega-3-acid Ethyl Esters, Whole blood viscosity (WBV), Total cholesterol, Plasma proteins, Low-density lipoprotein cholesterol (LDL-C), Lipids