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Lipid-Modifying and Pleiotropic Effects of Gemfibrozil, Simvastatin and Pravastatin in Patients With Dyslipidemia.
AIM: To assess the lipid-modifying and pleiotropic effects of drugs of the statin group (simvastatin and pravastatin) and the fibrate group (gemfibrozil) in dyslipidemia patients. PATIENTS AND METHODS: Fifty eight patients with primary dysli pidemia were recruited for a 12-week treatment. Forty...
Tags: Gemfibrozil, Pravastatin, Simvastatin, Plasma viscosity (PV), Hematocrit (Hct) (or packed cell volume PCV, erythrocyte volume fraction EVF), Total cholesterol, Low-density lipoprotein cholesterol (LDL-C), Apolipoprotein A-I (apo A-I), Lipids, Antithrombin III, Triglycerides, High-density lipoprotein cholesterol (HDL-C), Apolipoprotein B (ApoB), Platelet aggregation, Platelet factor 4 (PF4), Platelets (or thrombocytes), α2-macroglobulins, Fibrinogen
Effect of Supplementation With Dietary Seal Oil on Selected Cardiovascular Risk Factors and Hemostatic Variables in Healthy Male Subjects.
The average daily consumption of seal oil by the Inuit people is approximately 8-9 g, yet there is very little information on the effect of seal oil consumption on cardiovascular disease risk factors. In this study, 19 healthy, normocholesterolemic subjects consumed 20 g of encapsulated seal oil...
The possible antiatherogenic action of eicosapentaenoic acid (EPA) was pharmacologically investigated using purified and ethylesterified fish oilcontaining 75% EPA (EPA-E) in multiple oral doses in rats and rabbits. EPA-E showed dose-dependent prevention of thrombus formation in a vascular shunt...
Effect of HMG-CoA Reductase Inhibitors on Red Blood Cell Membrane Lipids and Haemorheological Parameters, in Patients Affected by Familial Hypercholesterolemia.
Eighteen patients with familial hypercholesterolemia treated with lovastatin (40 mg/day) for three months were studied to find out whether the drug induces modifications in the lipid composition of the erythrocyte membrane and whether these induce changes in the rheological behaviour of the red...
Tags: Lovastatin, Whole blood filterability (WBF), Lipids, Erythrocyte aggregation (RBC aggregation), Erythrocyte deformability
Effects of Long-Acting Propranolol and Verapamil on Blood Pressure, Platelet Function, Metabolic and Rheological Properties in Hypertension.
The newly developed antihypertensive drugs, the long-acting beta-blocker propranolol and the sustained release calcium antagonist verapamil, arecompared in their antihypertensive, platelet function, rheological properties and metabolic effects. The trial was a double-blind, randomised, placebo-...
Tags: Verapamil, Propranolol, Plasma viscosity (PV), Whole blood viscosity (WBV), Fibrinogen, Erythrocyte deformability, Low-density lipoprotein cholesterol (LDL-C), High-density lipoprotein cholesterol (HDL-C), Platelets (or thrombocytes), Lipids, Platelet activation, Platelet aggregation
Administration of Dietary Fish Oil Capsules in Healthy Middle-Aged Japanese Men With a High Level of Fish Consumption.
The nutritional effects of fish oil, which is rich in the n-3 polyunsaturated fatty acids, have been reported. In this randomized, placebo-controlled,double-blind, crossover study, we evaluated the effects of dietary fish oil capsules on the hematological parameters of healthy middle-aged...
Tags: Omega-3-acid Ethyl Esters, Whole blood viscosity (WBV), Total cholesterol, Plasma proteins, Low-density lipoprotein cholesterol (LDL-C), Lipids
Effect of Omega-3 Fatty Acids in Diet of Type I Diabetic Subjects on Lipid Values and Hemorheological Parameters.
Twelve type I (insulin-dependent) diabetic subjects in stable metabolic control for at least 3 mo received a controlled diet containing 50%carbohydrate, 35% fat, and 15% protein. Calorie intake varied from 1800 to 2200 calories, depending on individual needs. Part of the polyunsaturatedomega-6...
Tags: Omega-3-acid Ethyl Esters, Plasma viscosity (PV), Whole blood viscosity (WBV), Lipids, Triglycerides, High-density lipoprotein cholesterol (HDL-C)
Lovastatin Therapy in Heterozygous Familial Hypercholesterolaemic Patients: Effect on Blood Rheology and Fibrinogen Levels.
Thirteen heterozygous familial hypercholesterolaemic patients were treated with lovastatin for 1 year, and were investigated for the effect on lipid profile, blood rheology and fibrinogen levels. A significant dose-dependent reduction in serum levels of total and LDL-cholesterol, Apo B and the...
Tags: Lovastatin, High-density lipoprotein cholesterol (HDL-C), Low-density lipoprotein cholesterol (LDL-C), Apolipoprotein B (ApoB), Lipids, Total cholesterol, Fibrinogen, Red cell filterability
Effects of Atorvastatin Versus Fenofibrate on Lipoprotein Profiles, Low-Density Lipoprotein Subfraction Distribution, and Hemorheologic Parameters in Type 2 Diabetes Mellitus With Mixed Hyperlipoproteinemia.
Diabetic dyslipoproteinemia characterized by hypertriglyceridemia, low high-density lipoprotein (HDL) cholesterol, and often elevated low-density lipoprotein (LDL) cholesterol with predominance of small, dense LDL is a strong risk factor for atherosclerosis. It is unclear whether fibrate or...
Tags: Fenofibrate, Atorvastatin, Lipids, Fibrinogen, Plasma viscosity (PV), Erythrocyte aggregation (RBC aggregation), Triglycerides, High-density lipoprotein cholesterol (HDL-C), Low-density lipoprotein cholesterol (LDL-C)
Reports suggest that the low incidence of ischaemic heart disease in Greenlandic Eskimos is related to the effect of a diet rich in eicosapentaenoicacid on platelet reactivity and plasma lipid concentrations. A double blind randomised investigation was therefore conducted of the effects on...
Tags: Omega-3-acid Ethyl Esters, Platelet activation, Whole blood viscosity (WBV), Triglycerides, Lipids