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Effects of "Newer" and "Older" Antihypertensive Drugs on Hemorrheological, Platelet, and Endothelial Factors. A Substudy of The Anglo-Scandinavian Cardiac Outcomes Trial.
BACKGROUND: Different antihypertensive therapies may exert benefits via not only a reduction in blood pressure but also in improving the risk of thrombosis. METHODS: We tested the hypothesis that a more modern antihypertensive drug regimen (ie, amlodipine +/- perindopril) would have a more...
Tags: Amlodipine, Plasma viscosity (PV), Hematocrit (Hct) (or packed cell volume PCV, erythrocyte volume fraction EVF), White blood cells (WBC) (or leukocytes), von Willebrand factor (vWF), Fibrinogen, P-selectin
Abnormalities of Hemorheological, Endothelial, and Platelet Function in Patients With Chronic Heart Failure in Sinus Rhythm: Effects of Angiotensin-Converting Enzyme Inhibitor and Beta-Blocker Therapy.
BACKGROUND: To investigate the hypothesis that abnormalities of hemorheological (fibrinogen, plasma viscosity), endothelial (von Willebrand factor [vWF]), and platelet (soluble P-selectin) function would exist in patients with chronic heart failure (CHF) who are in sinus rhythm, we conducted a...
Effects of Omega-3 Polyunsaturated Fatty Acids on Plasma Indices of Thrombogenesis and Inflammation in Patients Post-Myocardial Infarction.
OBJECTIVE: To determine the effects of n-3 PUFAs supplementation on plasma indices of coagulation (fibrinogen), fibrin D-Dimer (an index ofthrombogenesis and fibrin turnover), endothelial damage/dysfunction (von Willebrand factor (vWf)), platelet activation (soluble P-selectin (sP-sel))...
Tags: Omega-3-acid Ethyl Esters, Total cholesterol, Low-density lipoprotein cholesterol (LDL-C), Triglycerides, P-selectin, Platelet activation, von Willebrand factor (vWF), Fibrinogen, Inflammation, Lipids, Plasma proteins