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To assess the effect of lovastatin on blood rheology, the hemorheological determinants fibrinogen, red cell aggregation, plasma viscosity, hematocrit and platelet aggregation (spontaneous and ADP-induced) were studied in 15 patients with type II hyperlipoproteinemia in the course of treatment...
Tags: Lovastatin, Fibrinogen, Erythrocyte aggregation (RBC aggregation), Plasma viscosity (PV), Total cholesterol, Triglycerides, Platelet aggregation, Hematocrit (Hct) (or packed cell volume PCV, erythrocyte volume fraction EVF)
Effects of Hormone Replacement Therapy on Plasma Viscosity and Doppler Variations in Postmenopausal Non-Smokers and Heavy Smokers.
OBJECTIVES: To evaluate the effects of transdermal hormone replacement therapy (HRT) on some biological cardiovascular risk factors, specificallythromboxane B2 level and plasma viscosity. Furthermore, we investigated Doppler flow modifications at the level of the uterine, internal carotid,...
Tags: Ethinyl Estradiol and Medroxyprogesterone, Erythrocyte aggregation (RBC aggregation), Platelet aggregation, Plasma viscosity (PV), Erythrocyte deformability
High-Dose Atorvastatin Treatment in Patients With Peripheral Arterial Disease: Effects on Platelet Aggregation, Blood Rheology and Plasma Homocysteine.
BACKGROUND: Statins are used for the treatment of hypercholesterolemia. Although they are well known to have pleiotropic effects, their dose-dependent influence on platelet aggregation, hemorheologic properties and the plasma levels of homocysteine in patients with peripheral arterial disease (...
Tags: Atorvastatin, Erythrocyte aggregation (RBC aggregation), Whole blood viscosity (WBV), Plasma viscosity (PV), Hematocrit (Hct) (or packed cell volume PCV, erythrocyte volume fraction EVF), Platelets (or thrombocytes), Platelet aggregation
Effects of Carvedilol on Common Carotid Arterial Flow, Peripheral Hemodynamics, and Hemorheologic Variables in Hypertension.
The effects of a beta-blocker, carvedilol, on peripheral hemodynamics and hemorheologic parameters were evaluated in 11 geriatric patients with essential hypertension [3 men and 8 women aged 62-79 years (mean, 68.6 years)]. Carvedilol was given orally after breakfast at a dose of 10 or 20 mg...
Tags: Carvedilol, Erythrocyte aggregation (RBC aggregation), Platelet aggregation, Plasma viscosity (PV), Erythrocyte deformability
Evidence for the usefulness of hydroxychloroquine as prophylaxis against thromboembolism after total hip replacement is examined. This agent causes reduction in red blood cell aggregation without prolonging the bleeding time in humans and, experimentally, reduces the size of the thrombus. There...
Tags: Hydroxychloroquine, Erythrocyte aggregation (RBC aggregation), Whole blood viscosity (WBV), Platelet aggregation
Effects of Low-Dose EPA-E on Glycemic Control, Lipid Profile, Lipoprotein(a), Platelet Aggregation, Viscosity, and Platelet and Vessel Wall Interaction in NIDDM.
OBJECTIVE: To assess the effects of low-dose eicosapentaenoic acid-ethyl-ester on diabetes regulation, lipid metabolism, blood rheology, andplatelet reactivity. RESEARCH DESIGN AND METHODS: In a double-blind, randomized, placebo-controlled study, 24 NIDDM subjects received 1800 mg of EPA-E, 900...
Tags: Omega-3-acid Ethyl Esters, Plasma viscosity (PV), Whole blood viscosity (WBV), Platelet activation, Platelet aggregation, Low-density lipoprotein cholesterol (LDL-C), Apolipoprotein B (ApoB), Erythrocyte deformability
Lipid-Modifying and Pleiotropic Effects of Gemfibrozil, Simvastatin and Pravastatin in Patients With Dyslipidemia.
AIM: To assess the lipid-modifying and pleiotropic effects of drugs of the statin group (simvastatin and pravastatin) and the fibrate group (gemfibrozil) in dyslipidemia patients. PATIENTS AND METHODS: Fifty eight patients with primary dysli pidemia were recruited for a 12-week treatment. Forty...
Tags: Gemfibrozil, Pravastatin, Simvastatin, Plasma viscosity (PV), Hematocrit (Hct) (or packed cell volume PCV, erythrocyte volume fraction EVF), Total cholesterol, Low-density lipoprotein cholesterol (LDL-C), Apolipoprotein A-I (apo A-I), Lipids, Antithrombin III, Triglycerides, High-density lipoprotein cholesterol (HDL-C), Apolipoprotein B (ApoB), Platelet aggregation, Platelet factor 4 (PF4), Platelets (or thrombocytes), α2-macroglobulins, Fibrinogen
Effects of Long-Acting Propranolol and Verapamil on Blood Pressure, Platelet Function, Metabolic and Rheological Properties in Hypertension.
The newly developed antihypertensive drugs, the long-acting beta-blocker propranolol and the sustained release calcium antagonist verapamil, arecompared in their antihypertensive, platelet function, rheological properties and metabolic effects. The trial was a double-blind, randomised, placebo-...
Tags: Verapamil, Propranolol, Plasma viscosity (PV), Whole blood viscosity (WBV), Fibrinogen, Erythrocyte deformability, Low-density lipoprotein cholesterol (LDL-C), High-density lipoprotein cholesterol (HDL-C), Platelets (or thrombocytes), Lipids, Platelet activation, Platelet aggregation
The possible antiatherogenic action of eicosapentaenoic acid (EPA) was pharmacologically investigated using purified and ethylesterified fish oilcontaining 75% EPA (EPA-E) in multiple oral doses in rats and rabbits. EPA-E showed dose-dependent prevention of thrombus formation in a vascular shunt...
Effects of Perindopril and Carvedilol on Endothelium-Dependent Vascular Functions in Patients With Diabetes and Hypertension.
OBJECTIVE: To compare the effects of the ACE inhibitor perindopril and the beta-blocker carvedilol on blood pressure and endothelial functions inNIDDM patients with hypertension. RESEARCH DESIGN AND METHODS: We conducted a double-blind randomized trial in 26 patients with NIDDM and mild...