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Effects of Lisinopril and Hydrochlorothiazide on Platelet Function and Blood Rheology in Essential Hypertension: A Randomly Allocated Double-Blind Study.
AIM: To compare the effects of an angiotensin converting enzyme (ACE) inhibitor and a thiazide diuretic on platelet function and haemorrheologicalvariables, since these factors may contribute to the atherosclerotic and thrombotic complications associated with hypertension. METHODS: Following a 2-...
Tags: Lisinopril, Hydrochlorothiazide, Whole blood viscosity (WBV), Hematocrit (Hct) (or packed cell volume PCV, erythrocyte volume fraction EVF), Red cell filterability, Plasma viscosity (PV), Erythrocyte aggregation (RBC aggregation), Shear rate, Shear stress (or wall shear stress WSS, endothelial shear stress ESS, vascular shear stress)
1. The shear stress of flowing blood profoundly influences the release of endothelium-dependent vasodilative and constrictive factors. Conversely, the influence of these mediators such as nitric oxide (NO) or endothelin-1 (ET-1) on blood rheology remains elusive. In the present study the...
Tags: Nitroglycerin, Whole blood viscosity (WBV), Shear rate, Shear stress (or wall shear stress WSS, endothelial shear stress ESS, vascular shear stress)
Blood and plasma viscosity was measured in 13 patients with hypothyroidism before and during replacement therapy with l-thyroxine. Blood viscositywas measured at natural hematocrit and after adjustment to 40%. The values were compared to those of 12 healthy subjects. Both blood viscosity...
Tags: Levothyroxine, Whole blood viscosity (WBV), Plasma viscosity (PV), Shear rate, Hematocrit (Hct) (or packed cell volume PCV, erythrocyte volume fraction EVF), Erythrocyte sedimentation rate (ESR)
Erythrocyte Deformability and White Blood Cell Count are Associated With Aspirin Resistance in High-Risk Vascular Patients.
Recently the phenomenon of aspirin resistance has been object of several studies, but no data are available on the possible role of thehaemorheologic parameters in affecting platelet function and resistance to antiplatelet agents. Aim of our study was to evaluate platelet function and...
Tags: Clopidogrel, Whole blood viscosity (WBV), Erythrocyte aggregation (RBC aggregation), White blood cells (WBC) (or leukocytes), Erythrocyte deformability, Plasma viscosity (PV), Shear rate
Smoking and Relation to Other Risk Factors in Postmenopausal Women With Coronary Artery Disease, With Particular Reference to Whole Blood Viscosity and Beta-Cell Function.
OBJECTIVES: To investigate possible associations between smoking habits and other coronary risk factors in postmenopausal women with knowncoronary heart disease (CHD). SETTING: The study was conducted at a university clinic. SUBJECTS: A total of 118 postmenopausal women with CHD verified with...
Hemorheological Changes and Characteristic Parameters Derived From Whole Blood Viscometry in Chronic Heroin Addicts.
A group of 15 chronic opioid addicts (DA) with mean age 26.5+/-7.3 years was studied by means of a rotational Contraves Low Shear 30 viscometer and the results have been compared with a control group of 19 healthy subjects. It was found that the mean whole blood viscosity values of the...
Tags: Methadone, Hematocrit (Hct) (or packed cell volume PCV, erythrocyte volume fraction EVF), Shear rate, Whole blood viscosity (WBV), Yield stress, Erythrocyte aggregation (RBC aggregation)
Lower Plasma Noradrenaline and Blood Viscosity on Carvedilol vs Atenolol in Men With Recent Myocardial Infarction.
The Carvedilol Acute Myocardial Infarction Study (CAMIS) investigates cardiac remodeling in patients (n = 250) randomized to carvedilol vs atenololand treated for 12 months after acute myocardial infarction. In a sub-study, we compared sympathetic, hemorrheological and vascular effects in small...
Effect of Testosterone Undecanoate on Hematological Profiles, Blood Lipid and Viscosity and Plasma Testosterone Level in Castrated Rabbits.
OBJECTIVE: The association between testosterone replacement therapy and cardiovascular risk remains controversial. Blood viscosity is a known individual risk factor for cardiovascular disease mortality. The objective of the present study was to investigate the effects of the long-acting...
Tags: Testosterone, Whole blood viscosity (WBV), Hematocrit (Hct) (or packed cell volume PCV, erythrocyte volume fraction EVF), Low-density lipoprotein cholesterol (LDL-C), High-density lipoprotein cholesterol (HDL-C), Shear rate, Triglycerides, Total cholesterol, Fibrinogen
Inhibition of the ouabain-sensitive Na-K-ATPase by digoxin significantly decreases erythrocyte deformability (5). Since first a decrease in this transport system has been discussed as a pathogenetic factor in the development of essential hypertension and second an increase in blood viscosity, due...
Tags: Digoxin, Whole blood viscosity (WBV), Shear rate, Fibrinogen, Erythrocyte deformability, Hematocrit (Hct) (or packed cell volume PCV, erythrocyte volume fraction EVF)
A Human Model of Platelet-Leucocyte Adhesive Interactions During Controlled Ischaemia in Patients With Peripheral Vascular Disease.
AIMS: In humans, little is known about the effects of platelet-leucocyte interactions on blood viscosity and microvascular perfusion. This study testedthe hypotheses that (1) activation and interactions between platelets and leucocytes may have an impact on microvascular blood viscosity...
Tags: Clopidogrel, Whole blood viscosity (WBV), Platelet aggregation, Platelets (or thrombocytes), Shear rate, White blood cells (WBC) (or leukocytes)