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Effects of Lisinopril and Hydrochlorothiazide on Platelet Function and Blood Rheology in Essential Hypertension: A Randomly Allocated Double-Blind Study.
AIM: To compare the effects of an angiotensin converting enzyme (ACE) inhibitor and a thiazide diuretic on platelet function and haemorrheologicalvariables, since these factors may contribute to the atherosclerotic and thrombotic complications associated with hypertension. METHODS: Following a 2-...
Tags: Lisinopril, Hydrochlorothiazide, Whole blood viscosity (WBV), Hematocrit (Hct) (or packed cell volume PCV, erythrocyte volume fraction EVF), Red cell filterability, Plasma viscosity (PV), Erythrocyte aggregation (RBC aggregation), Shear rate, Shear stress (or wall shear stress WSS, endothelial shear stress ESS, vascular shear stress)
Haemorheological Disturbances in Hypertensive Type 2 Diabetic Patients -- Influence of Antihypertensive Therapy.
Haemorheological changes have been described in hypertension as well as in diabetes mellitus. Antihypertensive treatment improves rheology inhypertensive patients. The aim of this study was to describe the haemorheological profile and its impact on shear stress in hypertensive type 2 diabetes...
Tags: Enalapril, Amlodipine, Whole blood viscosity (WBV), Plasma viscosity (PV), Hematocrit (Hct) (or packed cell volume PCV, erythrocyte volume fraction EVF), Fibrinogen, Shear stress (or wall shear stress WSS, endothelial shear stress ESS, vascular shear stress)
Effects of Pravastatin on Cellular Ultrastructure and Hemorheology in Rats After Traumatic Head Injury.
Pravastatin has neuroprotective effects against aging but its role in brain injury remains unclear. This study evaluated the effects of pravastatin on theultrastructural changes and hemorheological parameters in rats after traumatic brain injury (TBI) of right parietal cortical contusion by a...
Tags: Pravastatin, Erythrocyte aggregation (RBC aggregation), Shear stress (or wall shear stress WSS, endothelial shear stress ESS, vascular shear stress), Plasma viscosity (PV), Erythrocyte deformability
Pravastatin Decreases Wall Shear Stress and Blood Velocity in the Internal Carotid Artery Without Affecting Flow Volume: Results From the PROSPER MRI Study.
BACKGROUND AND PURPOSE: Despite speculations, it is unknown whether statins affect wall shear stress (WSS). Therefore, the effect ofpravastatin on WSS was investigated. METHODS: In 355 elderly individuals participating in the PROSPER study (follow up after 3 years), the effect of 40 mg...
Tags: Pravastatin, Shear stress (or wall shear stress WSS, endothelial shear stress ESS, vascular shear stress)
1. The shear stress of flowing blood profoundly influences the release of endothelium-dependent vasodilative and constrictive factors. Conversely, the influence of these mediators such as nitric oxide (NO) or endothelin-1 (ET-1) on blood rheology remains elusive. In the present study the...
Tags: Nitroglycerin, Whole blood viscosity (WBV), Shear rate, Shear stress (or wall shear stress WSS, endothelial shear stress ESS, vascular shear stress)
Haemoconcentration, Shear-Stress Increase and Carotid Artery Diameter Regulation After Furosemide Administration in Older Hypertensives.
The aim of the present study was to determine whether changes of carotid wall shear stress induced by changes in blood viscosity after diureticadministration cause carotid arterial dilatation in elderly hypertensives, as reported in the cat. Arterial wall shear rate (ultrasound technique,...
Tags: Furosemide, Whole blood viscosity (WBV), Shear stress (or wall shear stress WSS, endothelial shear stress ESS, vascular shear stress)
Hemodynamic, Hemostatic, and Endothelial Reactions to Psychological and Physical Stress in Coronary Artery Disease Patients.
Episodes of psychological and physical stress may elicit thrombotic cardiac events, such as myocardial infarction. These events are triggered when there are concurrent hemodynamic, hemostatic, and endothelial abnormalities. Hemodynamic, hemostatic, and endothelial reactions of 72 (15 women, 57...
Gender Specific Sympathetic and Hemorrheological Responses to Mental Stress in Healthy Young Subjects.
OBJECTIVE: Activation of the sympathetic nervous system may increase hematocrit (Hct), whole blood viscosity (WBV), and possibly cardiovascular risk. The aim was to study gender specific differences of mental stress on sympathetic reactivity and blood rheology. METHODS: Responses in blood...
Time Course and Mechanisms of Mental Stress-Induced Changes and Their Recovery: Hematocrit, Colloid Osmotic Pressure, Whole Blood Viscosity, Coagulation Times, and Hemodynamic Activity.
The mechanisms for stress-induced changes in hematocrit and blood viscosity are unclear. Twenty-two males completed experimental (30 min baseline, 10 min mental stress, 30 min recovery) and no-stress control conditions (70 min). Hemostatic and hemodynamic activity were measured throughout....
Blood Viscosity: Effects of Mental Stress and Relations to Autonomic Nervous System Function and Insulin Sensitivity.
We studied effects of mental stress on whole-blood viscosity (WBV) and blood pressure (BP), and relations between WBV and autonomic nervoussystem activity and insulin sensitivity. We measured WBV (rotational rheometer), plasma noradrenaline (NA), finger BP, heart rate variability (HRV) and...