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Effects of Omega-3 Polyunsaturated Fatty Acids on Plasma Indices of Thrombogenesis and Inflammation in Patients Post-Myocardial Infarction.
OBJECTIVE: To determine the effects of n-3 PUFAs supplementation on plasma indices of coagulation (fibrinogen), fibrin D-Dimer (an index ofthrombogenesis and fibrin turnover), endothelial damage/dysfunction (von Willebrand factor (vWf)), platelet activation (soluble P-selectin (sP-sel))...
Tags: Omega-3-acid Ethyl Esters, Total cholesterol, Low-density lipoprotein cholesterol (LDL-C), Triglycerides, P-selectin, Platelet activation, von Willebrand factor (vWF), Fibrinogen, Inflammation, Lipids, Plasma proteins
Relationship Between Plasma Essential Fatty Acids and Smoking, Serum Lipids, Blood Pressure and Haemostatic and Rheological Factors.
We aimed to determine whether levels of plasma fatty acids are correlated with other potential risk factors for cardiovascular disease, using a sampleof patients from a cross-sectional survey of the general population, in the City of Edinburgh. 306 men and women aged 55-74 years of whom half...
Tags: Omega-3-acid Ethyl Esters, Plasma viscosity (PV), Whole blood viscosity (WBV), Lipids, Triglycerides, Fibrinogen, High-density lipoprotein cholesterol (HDL-C)
The effect of simvastatin in 27 patients with severe primary hypercholesterolaemia was assessed by a double-blind placebo controlled parallel grouptrial. Total serum cholesterol, LDL-cholesterol and apoprotein B (ApoB) were significantly reduced by simvastatin 40 mg daily. Reductions...
Tags: Simvastatin, Total cholesterol, Low-density lipoprotein cholesterol (LDL-C), Very low-density lipoprotein cholesterol (VLDL-C), High-density lipoprotein cholesterol (HDL-C), Apolipoprotein A-I (apo A-I), Apolipoprotein B (ApoB), Triglycerides, Fibrinogen, Plasma viscosity (PV), Whole blood viscosity (WBV)
Effects of Sorbinicate and Nicotinic Acid on Blood Viscosity, Red Cell Deformation and Platelet Function.
Nicotinic acid (NA) and a retard derivative, sorbinicate, were investigated for their effects on blood rheology and platelet function, after oral administration, in two groups of patients with lower limb atherosclerosis obliterans — the second group having diabetes also. Red cell deformation and...
Tags: Niacin, Plasma viscosity (PV), Fibrinogen, Total cholesterol, Triglycerides, Erythrocyte deformability
Primary Chylomicronemia in Patients With Severe Familial Hypertriglyceridemia Responds to Long-Term Treatment With (n-3) Fatty Acids.
Because it disturbs microcirculation, chylomicronemia can cause severe clinical complications such as acute pancreatitis. Dietary measures are very important in the prevention and treatment of this condition. Dietary supplementation with (n-3) fatty acids has been shown to be of benefit in short-...
Tags: Omega-3-acid Ethyl Esters, Triglycerides, Plasma viscosity (PV), Chylomicrons, Apolipoprotein B (ApoB), Lipids, Fibrinogen
Elevated plasma viscosity is a predictor of atherosclerotic vascular disease and is a potential mechanism by which hypertriglyceridemia increasescardiovascular risk. Previous studies of plasma viscosity reduction in hypertriglyceridemic patients used medications that lowered both triglycerideand...
Short-Term Effect of Low-Dose Atorvastatin on Haemorrheological Parameters, Platelet Aggregation and Endothelial Function in Patients With Cerebrovascular Disease and Hyperlipidaemia.
INTRODUCTION AND OBJECTIVE: Haemorrheological parameters and endothelial function are known to be altered in vascular diseases, including stroke. Treatment with HMG-CoA reductase inhibitors ('statins') improves cerebrovascular (and cardiovascular) morbidity and mortality in patients with...
Tags: Atorvastatin, Total cholesterol, von Willebrand factor (vWF), Triglycerides, Low-density lipoprotein cholesterol (LDL-C), Whole blood viscosity (WBV), Platelet aggregation, Erythrocyte deformability
Effects of Doxazosin on Hemorheological, Hemodynamic and Lipid Parameters in Patients With Essential Hypertension.
It is known from previous studies that hemorheological parameters are altered in patients with essential hypertension. The hemorheological and hemodynamical effects of doxazosin, a selective alpha-1-adrenoreceptor blocker agent, was examined in twenty patients (mean age: 54+/-10 years) with...
Tags: Doxazosin, Whole blood viscosity (WBV), Lipids, Hematocrit (Hct) (or packed cell volume PCV, erythrocyte volume fraction EVF), Fibrinogen, Total cholesterol, Triglycerides, Adjusted whole blood viscosity (or hematocrit-corrected blood viscosity, normalized for Hct), Plasma viscosity (PV)
Reports suggest that the low incidence of ischaemic heart disease in Greenlandic Eskimos is related to the effect of a diet rich in eicosapentaenoicacid on platelet reactivity and plasma lipid concentrations. A double blind randomised investigation was therefore conducted of the effects on...
Tags: Omega-3-acid Ethyl Esters, Platelet activation, Whole blood viscosity (WBV), Triglycerides, Lipids
Effects of Losartan on Insulin Sensitivity in Severe Hypertension: Connections Through Sympathetic Nervous System Activity?
Angiotensin II (Ang II) is one of the most potent vasoconstrictors, and the first specific and orally available Ang II-receptor antagonist, losartan (MK-954, DuP-753), has now come into clinical use. The primary site of insulin resistance, as measured by the glucose clamp technique, is skeletal...
Tags: Losartan, Whole blood viscosity (WBV), Hematocrit (Hct) (or packed cell volume PCV, erythrocyte volume fraction EVF), Fibrinogen, Blood glucose, Total cholesterol, Triglycerides