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Reports suggest that the low incidence of ischaemic heart disease in Greenlandic Eskimos is related to the effect of a diet rich in eicosapentaenoicacid on platelet reactivity and plasma lipid concentrations. A double blind randomised investigation was therefore conducted of the effects on...
Tags: Omega-3-acid Ethyl Esters, Platelet activation, Whole blood viscosity (WBV), Triglycerides, Lipids
Reduced Red Cell Deformability Associated With Blood Flow and Platelet Activation: Improved by Dipyridamole Alone or Combined With Aspirin.
OBJECTIVES: To explore the role of blood flow in red blood cell deformability and determine whether it is associated with the release of ATP by redcells. METHODS: A perfusion system was employed to mimic the blood flow conditions. Red cell treatment in vitro with dipyridamole or aspirin, either...
Tags: Dipyridamole and Aspirin, Dipyridamole, Aspirin, Whole blood viscosity (WBV), Erythrocyte deformability
Effect of Losartan on Haematology and Haemorheology in Elderly Patients With Essential Hypertension: A Pilot Study.
This small open study in elderly patients with essential hypertension investigated the effects of the angiotensin II AT1 receptor antagonist on red blood cell haematology and haemorheology. Administration of losartan over a 1-year period was not associated with a significant reduction in...
Pentoxifylline Reduces Nephrotoxicity Associated With Cyclosporine in the Rat by its Rheological Properties.
BACKGROUND: The goals of this study were to evaluate whether administration of pentoxifylline (POF) reduces the nephrotoxicity associated withcyclosporine (CsA) in the rat, and whether the effect of POF is related to its rheological properties. METHODS: Mean arterial pressure was measured by an...
Effects of Nitroglycerin on Erythrocyte Rheology and Oxygen Unloading: Novel Role of S-Nitrosohemoglobin in Relieving Myocardial Ischemia.
BACKGROUND: We hypothesized that nitroglycerin improves O2 delivery to ischemic tissue by altering erythrocyte rheology and O2 unloadingthrough an increase in bioactive nitric oxide (NO) content. METHODS AND RESULTS: Twelve dogs with resting flow-reducing single-vessel stenosis were studied at...