You are here
BACKGROUND: Omega-3 fatty acids are established as being effective in the treatment and prevention of coronary artery disease. It is possible that they may also benefit people with peripheral arterial disease, since the pathogenesis of the two conditions is similar. OBJECTIVES: To determine the...
Tags: Omega-3-acid Ethyl Esters, Plasma viscosity (PV), Total cholesterol, Low-density lipoprotein cholesterol (LDL-C), Whole blood viscosity (WBV)
Effects of Losartan on Insulin Sensitivity in Severe Hypertension: Connections Through Sympathetic Nervous System Activity?
Angiotensin II (Ang II) is one of the most potent vasoconstrictors, and the first specific and orally available Ang II-receptor antagonist, losartan (MK-954, DuP-753), has now come into clinical use. The primary site of insulin resistance, as measured by the glucose clamp technique, is skeletal...
Tags: Losartan, Whole blood viscosity (WBV), Hematocrit (Hct) (or packed cell volume PCV, erythrocyte volume fraction EVF), Fibrinogen, Blood glucose, Total cholesterol, Triglycerides
OBJECTIVE: The endothelium plays a pivotal role in the regulation of vascular tone by releasing nitric oxide (NO). Increased availability of L-arginine, the natural precursor of NO, induces vasodilatation and inhibits platelet activity. We studied the effect of metformin on hemodynamic and...
Effect of Atorvastatin on Lipid Parameters, LDL Subtype Distribution, Hemorrheological Parameters and Adhesion Molecule Concentrations in Patients With Hypertriglyceridemia.
BACKGROUND AND AIM: Hypertriglyceridemia is a risk factor for atherosclerosis that is typically associated with high concentrations of adhesionmolecules, impaired hemorrheology and an unfavourable low-density lipoprotein (LDL) subtype distribution. We hypothesised that some of these riskmarkers...
Tags: Atorvastatin, Total cholesterol, Triglycerides, Low-density lipoprotein cholesterol (LDL-C), High-density lipoprotein cholesterol (HDL-C), Plasma viscosity (PV), Whole blood viscosity (WBV)
Effects of N-3 Fatty Acids and Fenofibrate on Lipid and Hemorrheological Parameters in Familial Dysbetalipoproteinemia and Familial Hypertriglyceridemia.
There is increasing evidence that hemorrheological abnormalities are associated with an enhanced risk of atherosclerosis. The n-3 fatty acids (n-3-FA) have been shown to have beneficial effects on atherosclerosis in patients with dyslipoproteinemias. We studied 23 patients with elevated plasma...
Tags: Fenofibrate, Omega-3-acid Ethyl Esters, Lipids, Whole blood viscosity (WBV), Shear rate, Plasma viscosity (PV), Fibrinogen, Erythrocyte aggregation (RBC aggregation), Very low-density lipoprotein cholesterol (VLDL-C)
Blood and plasma viscosity was measured in 13 patients with hypothyroidism before and during replacement therapy with l-thyroxine. Blood viscositywas measured at natural hematocrit and after adjustment to 40%. The values were compared to those of 12 healthy subjects. Both blood viscosity...
Tags: Levothyroxine, Whole blood viscosity (WBV), Plasma viscosity (PV), Shear rate, Hematocrit (Hct) (or packed cell volume PCV, erythrocyte volume fraction EVF), Erythrocyte sedimentation rate (ESR)
The effect of simvastatin in 27 patients with severe primary hypercholesterolaemia was assessed by a double-blind placebo controlled parallel grouptrial. Total serum cholesterol, LDL-cholesterol and apoprotein B (ApoB) were significantly reduced by simvastatin 40 mg daily. Reductions...
Tags: Simvastatin, Total cholesterol, Low-density lipoprotein cholesterol (LDL-C), Very low-density lipoprotein cholesterol (VLDL-C), High-density lipoprotein cholesterol (HDL-C), Apolipoprotein A-I (apo A-I), Apolipoprotein B (ApoB), Triglycerides, Fibrinogen, Plasma viscosity (PV), Whole blood viscosity (WBV)
Elevated Stress-Hemoconcentration in Major Depression is Normalized by Antidepressant Treatment: Secondary Analysis From a Randomized, Double-Blind Clinical Trial and Relevance to Cardiovascular Disease Risk.
BACKGROUND: Major depressive disorder (MDD) is an independent risk factor for cardiovascular disease (CVD); the presence of MDD symptoms in patients with CVD is associated with a higher incidence of cardiac complications following acute myocardial infarction (MI). Stress-hemoconcentration, a...
Tags: Fluoxetine, Whole blood viscosity (WBV), White blood cells (WBC) (or leukocytes), Hematocrit (Hct) (or packed cell volume PCV, erythrocyte volume fraction EVF)
Failure of Pentoxifylline or Cilostazol to Improve Blood and Plasma Viscosity, Fibrinogen, and Erythrocyte Deformability in Claudication.
Peripheral artery disease is associated with altered blood rheologic properties, including increased viscosity and decreased red blood cell (RBC)deformability. Pentoxifylline and cilostazol are available therapies for intermittent claudication. Improvement of blood viscosity and erythrocyte...
Tags: Cilostazol, Pentoxifylline, Whole blood viscosity (WBV), Lipids, Erythrocyte deformability, Fibrinogen, Erythrocyte sedimentation rate (ESR), Plasma viscosity (PV)
Calcium Antagonists and Thiazide Diuretics Have Opposite Effects on Blood Rheology and Radial Artery Compliance in Arterial Hypertension: A Randomized Double-Blind Study.
In addition to their effects on blood pressure, antihypertensive agents may produce additional effects on blood rheology and arterial complianceabnormalities which may play a role in target-organ damage. However, these effects may depend only on the specific pharmacological properties of certain...
Tags: Hydrochlorothiazide, Whole blood viscosity (WBV), Plasma viscosity (PV), Fibrinogen, Hematocrit (Hct) (or packed cell volume PCV, erythrocyte volume fraction EVF), Erythrocyte aggregation (RBC aggregation), Erythrocyte deformability, Shear rate